Telmisartan is a member of a family of drugs called angiotensin receptor blockers (), which includes losartan (), valsartan (), irbesartan (), and candesartan ().Angiotensin, formed in the blood by the action of angiotensin converting enzyme (ACE), is a powerful chemical that attaches to angiotensin receptors found in many tissues but primarily on muscle cells of blood vessels. Participants randomized to this group will receive daily placebo and health education lectures weekly for six months. Blood pressure < 100/50 after run-in or potassium >= 5.5 meq/L at the end of run-in. Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.. Studies of telmisartan in this setting do not exclude that it may not preserve a meaningful fraction of the effect of the ACE i nhibitor to which it was compared. If experienced, these tend to have a Less Severe expression 1. TELEX is a randomized controlled clinical trial (2 x 2 factorial design) of 112 participants with PAD randomized to one of four arms: Group A: telmisartan + supervised exercise therapy; Group B: telmisartan + a "no exercise" control group; Group C: placebo + supervised exercise therapy; and Group D: placebo + a "no exercise" control group. Your doctor may need to adjust your diabetes medication, exercise program, or diet. Telmisartan is an effective treatment of hypertension in once daily doses of 20 to 80 mg while amlodipine is effective in doses of 2.5 to 10 mg. Study record managers: refer to the Data Element Definitions if submitting registration or results information. How Telmisartan works Micardis (telmisartan) is an angiotensin II receptor antagonist used to treat high blood pressure (hypertension).Micardis is sometimes given together with other blood pressure medications. Ochsner is a 501(c)3 not-for-profit organization, founded on providing the best patient care, research, and education. Telmisartan 80 MG Tablet is used to treat high blood pressure, prevent stroke and other heart diseases. High blood pressure is also associated with the development of Alzheimer’s, studies have shown. Lowering blood pressure reduces the risk of fatal and nonfatal cardiovascular events, primarily strokes and myocardial infarctions. National Heart, Lung, and Blood Institute (NHLBI). Major medical illness including renal disease requiring dialysis, lung disease requiring oxygen, Parkinson's disease, a life-threatening illness with life expectancy less than six months, or cancer requiring treatment in the previous two years. Telmisartan is an angiotension receptor blocker (aka ARB). Blood pressure < 100/50 at baseline or potassium > 5.0 meq/L at baseline. [NOTE: potential participants may still qualify if they have had treatment for an early stage cancer in the past two years and the prognosis is excellent. Ochsner Patient Research Advisory Board (OPRAB), Institutional Animal Care and Use Committee (IACUC), Patient-Centered and Health Outcomes Research, Dr. John Ochsner Discovery Health Sciences Academy, Telmisartan Plus Exercise to Improve Functioning in Peripheral Artery Disease (TELEX). What Is Micardis? Participation in another clinical trial or cardiac rehabilitation or completion of a clinical trial or cardiac rehabilitation in the previous three months. Pharmacy Taking Micardis (telmisartan) to treat your high blood pressure, or hypertension, can lower your heart rate, but it is not a common side effect unless you sweat heavily while exercising. In rare cases, hydrochlorothiazide and telmisartan can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Consider using the ACE inhibitor first, and, if it is stopped for cough only, consider re-trying the ACE inhibitor after the cough resol ves. Based on promising preliminary evidence, we hypothesize that telmisartan, an oral angiotensin receptor blocker, will improve walking ability and prevent functional decline in people with PAD. Dosage must be individualized and may be increased after at least 2 weeks. Telmisartan and Amlodipine Dosage and Administration General Considerations. Does Telmisartan Interact with other Medications? Keep taking telmisartan as you have been told by your doctor or other health care provider, even if you feel well. Telmisartan is also used to decrease the chance of heart attack, stroke, or death in people 55 years of age or older who are at high risk for cardiovascular disease. Behavioral: Supervised Treadmill Exercise Therapy. > Class II NYHA heart failure or angina, increase in angina, angina at rest, or abnormal baseline treadmill stress test. Telmisartan 40 MG Tablet is used to treat high blood pressure, prevent stroke and other heart diseases. Flu-Like Symptoms 6. Telmisartan has a biochemical effect on muscle cells which is very similar to the effect of exercise. Severe hepatic impairment defined by two or more liver function enzyme values greater than 2.5 the upper limit of normal. First, an ABI <= 0.90 at the baseline study visit is an inclusion criterion for PAD. For general information, Learn About Clinical Studies. ClinicalTrials.gov Identifier: NCT02593110, Interventional Participants randomized to the exercise intervention will receive supervised treadmill exercise three times weekly for six months. In addition to the above criteria, investigator discretion will be used to determine if the trial is unsafe or not a good fit for the potential participant. This medicine is effective in elderly population who are at higher risk of developing heart diseases. Participants in this group will receive both daily telmisartan and supervised treadmill exercise three days weekly for six months. The pharmacokinetics of telmisartan are nonlinear over the dose range of 20—160 mg, with greater than proportional increases of plasma concentrations (Cmax and AUC) with increasing doses. one pill per day for > 10 days out of the 14 day run-in period). A proper diet and regular exercise should be maintained along with taking this medicine. Failure to successfully complete the 2-week study run-in, defined as failing to attend the health education and treadmill exercise run-in sessions and/or failing to take the study medication daily for 10 or more days in the two-week period (i.e. If the participant had a baseline eGFR performed by his/her physician within two months of the baseline eGFR for the TELEX trial, the participant's physician's eGFR may be considered the baseline measure, at the study principal investigator's discretion. The TELEX trial will also determine whether telmisartan plus supervised exercise improves walking performance more than either therapy alone. Third, potential participants with an ABI > 0.90 who have vascular lab evidence of PAD or angiographic evidence of PAD will be eligible. Micardis (telmisartan) is an angiotensin receptor blocker (ARB) used to treat high blood pressure and to reduce the risk of heart attack, stroke, or death from cardiovascular causes in patients 55 years of age or older unable to take ACE inhibitors. Please remove one or more studies before adding more. Micardis is also used to reduce the risk of stroke, heart attack, or death from heart problems in people who are at least 55 years old with risk factors for serious heart disorders. Telmisartan (brand name Micardis) is an angiotensin II receptor antagonist (angiotensin receptor blocker, ARB) used in the management of hypertension. “Tried telmisartan for HBP as my father was on it. The phase IV clinical study is created by eHealthMe based on reports of 2,054 people who have side effects when taking Telmisartan from the FDA, and is updated regularly. All participants will have PAD. A consequence of this is increased oxidative capacity of Type II muscle fibers, which may be called “switching” from Type IIb to Type IIa. Objective Altitude-related and exercise-related elevations in blood pressure (BP) increase the likelihood of developing pulmonary hypertension and high-altitude illness during high-altitude sojourn. Talk with your doctor and family members or friends about deciding to join a study. A Common Cold 2. Severe Interactions. Hydrochlorothiazide and telmisartan side effects. Buy Telmisartan 80 MG Tablet Online. Inflammation Of The Tissue Lining The Sinuses 7. COVID-19 is an emerging, rapidly evolving situation. We'd love to know more about you so we can deliver the most relevant content. In thi … Telmisartan is in a class of medications called angiotensin II receptor antagonists. We are one of the country’s largest non-university based academic medical centers. Stopped telmisartan, PVC's resolved in about 7-10 days. We will determine whether telmisartan therapy with or without exercise improves six-minute walk distance at 6-month follow-up, compared to placebo with or without exercise (i.e. It is broadly assumed that telmisartan has performance-enhancing effects well beyond the health-promoting benefits. This medicine is effective in elderly population who are at higher risk of developing heart diseases. Listing a study does not mean it has been evaluated by the U.S. Federal Government. A lack of fluids and heavy sweating can both cause your heart rate to slow, resulting in low blood pressure. Telmisartan Plus Exercise to Improve Functioning in Peripheral Artery Disease (TELEX) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Ochsner is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, age, national origin or ancestry, citizenship, sexual orientation, gender identity, veteran status, disability or any other protected characteristic under applicable law. It may not be the most popular anti-hypertension drug currently prescribed. It works by blocking a substance in the body that causes blood vessels to tighten. Did not resolve with beta-blocker. Telmisartan is a prescription medication used to treat high blood pressure. Telmisartan is used alone or in combination with other medications to treat high blood pressure. Telmisartan is an angiotensin II receptor blocker (ARB). Surgery including lower extremity revascularization, coronary revascularization with stenting, or orthopedic surgery during the past 3 months or anticipated in the next 6 months or myocardial infarction or stroke in the past 3 months. Congestive heart failure with an ejection fraction <40. Finally, potential participants with a history of lower extremity revascularization who do not meet the criterion above and have an ABI > 0.90 with a 20% or higher drop in ABI after heel-rise exercise will be eligible. Food slightly reduces telmisartan bioavailability, with a reduction in the AUC of about 6% with the 40 mg tablet and about 20% after a 160 mg dose. 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